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The world is full of overweight and obese people who find it impossible to lose weight by diet and exercise alone. Many of them are desperate to find a weight management product that can help them finally start making progress.

The FDA has already approved several pharmaceutical interventions ranging from diet pills like Phentermine and Xenical to weight loss jabs like Ozempic and Wegovy. Nevertheless, the demand for safe and effective weight loss medications continues to grow, and every time a fresh product appears on the horizon, it quickly becomes big news.

That’s the present situation with one of the latest drugs under development in the labs of Eli Lilly and Company. It’s called Retatrutide and thanks to media coverage of early successes in phase 2 clinical trials, more and more people are wanting to know more about it.

According to the company’s announcement at the American Diabetes Association’s annual meeting in June 2023, the new experimental weight loss drug helped participants in a phase 2 clinical trial to reduce their body weight by around 24%. Eli Lilly also shared the data in The New England Journal of Medicine. [1]

If the positive outcomes are validated in a larger phase 3 clinical trial, expected to be completed by late 2024 or 2025, there’s a good chance Retratrutide will gain FDA approval and become available as a prescription weight loss injection.

Cheaper and Natural Alternatives for Losing Weight

Here are the recommended otc diet pills that are available now.

#1 – PhenQ – OTC Fat Burner and Appetite Suppressant

CLICK to view PHENQ website and see latest price and special offers

Here are some positives of using the over-the-counter diet pill PhenQ as an alternative to prescription weight loss medications like Retarutide and similar injections that suppress appetite such as tirzepatide (Mounjaro), semaglutide (Wegovy), and semaglutide (Ozempic):

PhenQ is available without a prescription, so there’s no need to schedule and pay for doctor’s appointments to determine if you meet eligibility requirements.

It contains natural ingredients like capsicum, caffeine, and nopal that are clinically backed to help with appetite suppression, fat burning, and preventing new fat formation.

PhenQ appears to provide many of the same benefits as prescription drugs for weight loss, including reduced hunger, boosted energy, and faster metabolism. But without the high cost.

There are no reported serious side effects associated with PhenQ since it contains no harsh stimulants or artificial chemicals. Prescription medications come with warnings of potential adverse effects.

PhenQ often costs less than $70 per month, whereas prescription anti-obesity drugs can cost hundreds even with insurance. Mounjaro costs over $1000 out of pocket. Positive customer reviews and before and after photos suggest PhenQ provides significant weight loss results for many users.

There are discounts on multi-bottle purchases and a 60-day money back guarantee if you’re unsatisfied with results.

No doctor visits are required, you can order PhenQ diet pills conveniently online. Prescriptions can be a hassle to renew.

So for those seeking an affordable and side effect-free alternative to prescription weight loss meds, PhenQ is one of the top over-the-counter diet pills to consider.

#2 – Capsiplex – Non-Prescription Thermogenic Fat Burner

CLICK to view CAPSIPLEX website and see latest price and special offers

Capsiplex is an over-the-counter diet pill that leverages capsicum extract from red hot chili peppers as its primary active ingredient for weight loss.

It aims to help burn calories before, during, and after exercise by increasing thermogenesis, providing an energy boost, and suppressing appetite.

The capsaicin in capsicum stimulates the body to burn more calories through increased heat production and oxygen consumption.

It also inhibits new fat formation by impacting key enzymes. Capsiplex has an outer OmniBead coating designed for timed release to avoid gastric irritation.

By activating these multiple mechanisms of action in the body, Capsiplex can aid your efforts for fat loss when combined with regular exercise and healthy eating.

The capsicum gives Capsiplex its potency to target appetite, boost metabolism, and incinerate more calories and body fat.

What is Retatrutide?

Retatrutide is a new pharmaceutical compound that has generated significant interest in the field of weight management and obesity treatment. It’s a triple-hormone-receptor agonist, meaning it activates three specific receptors in the body. All of them play a role in weight regulation.

The three receptors targeted by Retatrutide are the glucagon-like peptide 1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor. By activating these receptors, Retatrutide works to regulate hunger, satiety, and energy expenditure, ultimately leading to weight loss.

GLP-1 and GIP are hormones that are released in response to food intake. They play a vital role in regulating blood sugar levels and promoting feelings of fullness. Glucagon stimulates the liver to release stored glucose into the bloodstream.

By activating the GLP-1, GIP, and glucagon receptors simultaneously, Retatrutide helps control appetite, increase feelings of fullness, regulate blood sugar levels, and promote the burning of stored fat.

Related content: New Ozempic pill for weight loss, when is it available?

Exploring Retatrutide’s Triple-Hormone-Receptor Agonist Properties

Retatrutide’s ability to target three key receptors sets it apart from a lot of the other popular weight loss injections. Most of them only simulate the actions of GLP-1.

However, as with weight loss medications such as Wegovy, the new drug’s ability to mimic GLP-1 plays a pivotal role in regulating appetite and satiety.

When activated by Retatrutide, GLP-1 enhances feelings of fullness and suppresses appetite. This makes it easier to follow a low-calorie diet plan without having to contend with hunger pangs.

The benefits are amplified by the activation of the GIP receptor, which also contributes to controlling appetite and promoting a sense of satisfaction after meals.

Additionally, Retatrutide’s interaction with the glucagon receptor helps regulate blood sugar levels and metabolism. Glucagon, when stimulated by Retatrutide, prompts the liver to release stored glucose into the bloodstream, providing a valuable source of energy while also directly aiding in weight loss.

The synergy created by the simultaneous activation of these three receptors sets Retatrutide apart as a unique weight loss solution. By addressing multiple aspects of weight regulation, it offers a comprehensive approach to tackling obesity and related metabolic disorders.

Furthermore, the triple-hormone-receptor agonist properties of Retatrutide make it a promising option not only for weight loss but also for individuals with type 2 diabetes.

The GLP-1 and GIP receptors’ activation helps improve insulin sensitivity and promote glucose control, making Retatrutide a potential therapeutic option for managing both conditions simultaneously.

As research into retatrutide’s triple-hormone-receptor agonist properties continues to unfold, it may open doors to new possibilities in the fight against obesity and metabolic disorders.

However, although there is a lot of excitement about the new drug’s possibilities, it’s important not to lose sight of the fact it’s still undergoing clinical trials and awaiting regulatory approval.

Latest news: How to get Ozempic for weight loss, cost price, copay and without insurance?

A Look at Clinical Trials and Weight Loss Results with Retatrutide

Recent clinical trials have shed light on the remarkable weight loss results associated with Retatrutide. Participants in these trials experienced significant reductions in body weight.

Obese adults who took part in a 48-week clinical trial funded by Eli Lilly achieved substantial reductions in body weight while they were being treated with Retatrutide. On average, participants taking 12 mg doses showed an astounding 24% reduction in body weight.

Eli Lilly shared this data in June 2023 at the American Diabetes Association’s annual meeting and simultaneously published it in The New England Journal of Medicine, attracting a lot of interest in the new drug. [1]

The results of a recent investigation published in The Lancet also endorse the efficacy of Retatrutide as a weight loss injection. In this case, the reductions in body weight were a little lower but the study period was shorter than that of the previous clinical trial.

Data from the study is consistent with the findings of the earlier study in The New England Journal of Medicine. Higher doses resulted in better results while also increasing the side effects.

Once again, the most common side effects were gastrointestinal complications, such as nausea, vomiting, constipation, and diarrhea. [2]

The study findings featured in Volume 32, Issue 5 of Expert Opinion on Investigational Drugs also bear mention.

The researchers highlight the pressing necessity for effective medications to combat obesity. However, after stating the efficacy of Retratrutide compares well to that of Semaglutide, they then emphasize the precise role of stimulating glucagon receptors in type 2 diabetes and/or obesity treatment remains inadequately defined, thus warranting additional elucidation. [3]

It is important to note that further studies, including longer-duration phase 3 trials, are underway to evaluate the efficacy and safety of Retatrutide.

Potential Risks of Using Retatrutide

Some general side effects noted in clinical trials include nausea, diarrhea, vomiting, constipation, and increased heart rate. These side effects are similar to those observed with other medications in the same class, such as Ozempic, Mounjaro, and Wegovy.

However, GLP-1 Receptor agonists also present additional concerns including an elevated risk of pancreatitis and greater susceptibility to cancers of the thyroid gland. [4, 5]

Presuming it gains FDA approval in the future, people considering using Retatrutide should discuss their risk factors and any potential side effects with their healthcare provider. This is especially important for those with a history of pancreatitis or thyroid issues.

How Retatrutide Compares to Alternative Weight Loss Medications

The information available to date suggests Retatrutide may offer better weight loss results than existing prescription weight loss medications such as Mounjaro (Tirzepatide), Wegovy (Semaglutide), and Saxenda (Liraglutide).

Data from clinical trials show weight loss percentages ranging from 21% to 24%. The aforementioned drugs are unable to match this.

It’s important to note that the comparisons between Retatrutide and existing medications are based on the present clinical trial data. If the drug becomes available via prescription, data from a larger pool of users may show it performs better or worse than is presently anticipated.

Retatrutide Vs Mounjaro (Tirzepatide)

Retatrutide and Mounjaro are both GLP-1 receptor agonists. They also mimic glucose-dependent insulinotropic polypeptide (GIP), so there are strong similarities.

However, in terms of superiority, Retatrutide appears to be an easy winner. Study results show weight loss percentages ranging from 21% to 24%. Clinical data relating to Mounjaro only shows weight loss percentages of around 12-15%.

On the other hand, Retatrutide has some failings. One major issue is that it has yet to get FDA approval. This means that its safety and efficacy have not been officially confirmed by regulatory authorities. It remains an experimental drug that may never make it to market.

Furthermore, as with all experimental drugs, there is very little information regarding Retatrutide’s long-term safety profile. More research and monitoring are necessary to gain a better understanding of any potential side effects or risks that may occur over time.

Retatrutide Vs Ozempic and Wegovy (Semaglutide)

All the data so far suggests Retatrutide may be more powerful than Ozempic and Wegovy and deliver superior weight loss results. This is not entirely surprising because Ozempic and Wegovy are only GLP-1 receptor agonists. Retatrutide targets two additional receptors as well.

Again, due to its experimental status, Retatrutide remains a wild card. Although it has some  gfailings as well, Wegovy has already succeeded in gaining FDA approval as a weight management drug.

Retatrutide Vs Saxenda (Liraglutide)

Saxenda is another popular weight-loss medication. It provides Liraglutide and has more in common with Wegovy than Retatrutide and Mounjaro because it only targets GLP-1 receptors.

Clinical data suggests Retatrutide is the most powerful of the two but, again, that’s not surprising because of its triple-whammy effect. [6]

The dosing schedule for the two drugs also differs considerably. Like Mounjaro and Wegovy, Reatrutide only requires one injection per week. People using Saxenda have to inject it every day, making it a more unpleasant option to choose.

How to Get Retatrutide

Here are the legitimate steps required to get Retatrutide:

• Schedule an appointment with your doctor to discuss your weight loss options.
• Your doctor will evaluate your medical history and BMI (body mass index) to see if you meet eligibility criteria. Typically a BMI of 30 or higher, or 27-29.9 with an obesity-related condition.
• If eligible, your doctor may prescribe Retatrutide along with diet, exercise and behavioral changes.
• The starting dose is 0.25 mg injected under the skin once weekly, increasing gradually over 16-20 weeks up to 2.4 mg.
• These drugs are only available by prescription and should be obtained through a licensed pharmacy under medical supervision.
• Expect regular follow-ups with your doctor to monitor side effects, weight loss progress and make dosage adjustments as needed.
• These medications are not intended for cosmetic weight loss and have risks like nausea, diarrhea, gallbladder issues.
• They are not recommended for those with certain medical conditions. Your doctor will determine if they are appropriate for you.
• Patience and commitment to lifestyle changes are needed, as weight loss results build over months of treatment.

In summary, speak to your doctor to determine if prescription semaglutide is an appropriate obesity treatment for your situation. There are no shortcuts – medical eligibility and supervision are essential.

Anticipating The Cost of Using Retatrutide for Weight Loss

Should it gain FDA approval, the cost of using Retatrutide is likely to be relatively high. Due to its similar nature, the price is likely to be similar to that of Mounjaor, Wegovy, and Saxenda. The cost of using these options is generally $1,300 to $1,500 per month.

However, although it’s reasonable to anticipate the cost of Retatrutide may fall within the same price range. It may even be more expensive due to its more comprehensive approach to appetite suppression and weight loss.

Although medical insurance may cover some or all of the costs, most medical insurance policies do not offer coverage for weight loss drugs.

Does Retatrutide Have Any Other Uses?

As of now, Retatrutide is being investigated primarily for its potential role in weight management, particularly in cases of obesity. However, due to its effects on glucagon-like peptide-1 (GLP-1) receptors, it may hold promise for managing type 2 diabetes, as GLP-1 receptor agonists can affect insulin production and blood glucose levels. However, these potential uses are still under study, and more research is needed to confirm the efficacy and safety of Retatrutide for these applications.

How do you use Retatrutide?

At present, Retatrutide is still undergoing clinical trials, and usage details may change based on the results of these studies. However, similar to other GLP-1 receptor agonists such as Wegovy and Saxenda, it’s likely that Retatrutide will be administered through subcutaneous injection.

Why is Retatrutide Significant?

Retatrutide is significant for several reasons. Firstly, it represents a new development in the field of weight loss medications. Its potential to offer weight loss percentages between 21% and 24% surpasses the current industry standard. Secondly, unlike other GLP-1 receptor agonists, Retatrutide simultaneously targets two additional receptors unlike most other weight loss drugs, potentially offering an enhanced overall effect on weight management.

Retatrutide FAQ

Q: How does the new weight loss drug Retatrutide work?

A: Retatrutide is an experimental drug that mimics the effects of glucagon like peptide 1 and glucose dependent insulinotropic polypeptide. These compounds help regulate blood sugar levels and appetite. In clinical trials, participants taking the highest dose of Retatrutide lost nearly a quarter of their body weight on average.

Q: How much weight can you lose with Retatrutide?

A: In mid stage clinical trials, those taking the highest dose of Retatrutide lost 29 lbs of body weight on average, compared to 19 lbs in the placebo group. It helped patients lose up to 13% of their body weight.

Q: Is Retatrutide more effective than other weight loss medications?

A: Retatrutide appears to offer greater weight loss benefits than other FDA approved weight loss drugs like Wegovy and Ozempic. However, more clinical trials are needed to directly compare Retatrutide to other weight loss medications.

Q: What are the side effects of Retatrutide?

A: As an experimental drug, the full side effect profile of Retatrutide is still being determined. In studies, some patients experienced nausea, diarrhea or constipation. Long term safety still needs further research.

Q: When will Retatrutide be available?

A: Retatrutide is being developed by Eli Lilly and is currently undergoing clinical trials at Yale Obesity Research Center and other sites. It may take several more years of testing before Retatrutide becomes widely available as a prescription weight loss medication.

Retatrutide Weight loss Drugs Summary

In terms of potential, Retatrutide could revolutionize the world of weight loss medications, offering users a more effective solution than the options currently available. However, it’s essential to remember that this drug remains in the experimental phase, and its efficacy and safety have not been fully validated by regulatory authorities.

Although preliminary data suggest promising results, the drug’s long-term safety profile and possible side effects are still largely unknown. Consequently, those interested in Retatrutide should keep a close eye on further developments while also considering existing FDA-approved weight loss medications or over-the-counter (OTC) supplements.

Latest Retatrutide Research Sources

1. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2301972
2. Retatrutide, a Gip, Glp-1 and Glucagon Receptor Agonist, for People With Type 2 Diabetes: A Randomised, Double-Blind, Placebo and Active-Controlled, Parallel-Group, Phase 2 Trial Conducted in the USA: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01053-X/fulltext
3. Is Retatrutide (LY3437943), a Glp-1, Gip, and Glucagon Receptor Agonist a Step Forward in the Treatment of Diabetes and Obesity?: https://www.tandfonline.com/doi/abs/10.1080/13543784.2023.2206560
4. Acute Pancreatitis During Glp-1 Receptor Agonist Treatment. A Case Report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808258/
5. Glp-1 Receptor Agonist-Associated Tumor Adverse Events: A Real-World Study From 2004 to 2021 Based on Faers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640975/
6. Liraglutide for Weight Management in the Real World: Significant Weight Loss Even if the Maximal Daily Dose Is Not Achieved: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820228/