The student media organization of California State University Northridge

Daily Sundial

The student media organization of California State University Northridge

Daily Sundial

The student media organization of California State University Northridge

Daily Sundial

Best Alternative to Linzess for IBS and Constipation – Cheaper and Natural Linzess Alternatives Over the Counter


Branded Content by Cosmic Press

Linzess is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing fluid in the intestines and helping speed up the movement of food through the gut. Linzess may improve stool texture and lessen symptoms associated with these conditions.

However, for some people, the side effects of Linzess may be too much to handle. Other people don’t want to take prescription drugs or medication or would prefer a natural alternative. Fortunately, there are a number of over-the-counter (OTC) products that can help.

Natural Alternative to Linzess – Snapshot

Here are the best and cheaper OTC Linzess alternatives available to buy in 2023:

1. YourBiology Gut+ 

2. Biotics 8

3. Health Nutrition 40 Billion

All three of the above are respected probiotic supplements that are produced by reputable manufacturers that offer long money-back guarantees. They are all available without prescription and cheaper than the prescription drug.

Probiotic Supplements Vs Laxatives and IBS Medications

Research shows probiotics can be very effective for treating constipation, along with other symptoms of irritable bowel syndrome, such as flatulence, nausea, and stomach pain. [1]

The problem with using Linzess and similar medications is they only provide temporary relief from IBS symptoms. The same is true for the herbal laxatives that many people buy over the counter.

It’s also worth noting that certain laxatives can cause metabolic disturbances and have the potential to damage the nerves in the colon. This can foster a situation where people have to rely on laxatives or they cannot poop and may need to keep raising the doses or using stronger options to get things moving. [2, 3]

Linzess can be particularly problematic. It’s associated with severe diarrhea and several other unpleasant side effects. Because of this, the FDA insists the drug information sheet include a black box warning about the risks of serious dehydration in children.

There are very good arguments for using probiotic supplements in place of laxatives and prescription constipation drugs such as Linzess. Instead of only addressing the symptoms and providing temporary relief, probiotics instigate favorable changes in the gut microbiome that provide natural relief.

Unfortunately, as with Linzess and the laxative medications that can treat chronic constipation, you need to take probiotics every day. However, once the supplements have optimized the gut microbiome and restored gut health, the daily maintenance doses will not cause metabolic disturbances, nerve damage, or other unwanted issues.

Probiotic supplements are arguably the best natural treatments for IBS and constipation and, after reviewing dozens of the most popular probiotic products, we discovered YourBiology Gut+, Biotics 8, and Health Nutrition 40 Billion are the three options that work best

Best Natural Linzess Alternatives Over the Counter

None of the probiotic supplements that work best for constipation and IBS were created specifically for use in these roles. They are marketed on the back of their ability to improve digestion, gut health, and immunity, and for improving health and wellness in various other ways.

However, all three of the supplements we selected provide species of probiotic bacteria that have proven to be very effective for treating irritable bowel syndrome and chronic idiopathic constipation (constipation with an unknown cause).

In short, we chose the three supplements we recommend because of the science, not what their manufacturers say.

#1 – YourBiology Gut+ (Best for Women)

CLICK to view YourBiology Gut+ website for price and special offers

YourBiology Gut+ is a probiotic supplement designed for women. In addition to providing some of the best probiotics for improving bowel movements, reducing abdominal pain, and tackling other gut issues due to IBS, the supplement also contains FOS. Yourbiology is also one of the most effective probiotics for leaky gut and IBD.

FOS (fructooligosaccharides) is one of the best forms of prebiotic fiber. Most of the top gut supplements have FOS in them to feed the good bacteria in the gut and help them to thrive.

The capsules also have a special coating that slows their disintegration. This protects the live bacteria from harsh stomach acids.

We recommend this supplement because it contains Lactobacillus plantarum (L. plantarum) and Bifidobacterium lactis (B. Lactis).

Research published in the World Journal of Gastroenterology and Annals of Translational Medicine (leading scientific journals) shows strains belonging to the L. plantarum bacteria species can be very effective in alleviating the symptoms of IBS and easing constipation. [4, 5]

There has always been a lot of interest in the abilities of B. Lactis. As with all probiotics, it’s very versatile and offers value in multiple areas of health and wellness.

The researchers wanted to discover which probiotics are effective for treating functional constipation in adults. After conducting a systematic review and meta-analysis of numerous clinical trials, they discovered B. lactis works best, noting its ability to significantly increase stool frequency and bowel movement. [6]

Research published in Frontiers in Nutrition is equally supportive of the probiotic’s abilities, especially for improving stool transit time and fecal consistency in people suffering from IBS-C (IBS constipation). [7]

In addition to providing probiotic bacteria that can treat IBS-C, YourBiology Gut+ provides probiotics that help balance vaginal flora and deliver other benefits of particular interest to women such as combating menopause weight gain and other symptoms of the change of life. For women with IBS or constipation, it’s the best probiotic supplement overall.


  • Specially formulated for women
  • Shelf-stable (does not require refrigeration)
  • Provides probiotics proven to be effective for constipation and IBS
  • Contains FOS prebiotic fiber
  • The capsules have a special protective coating
  • Supports female health and vitality in several ways
  • Possible to get 3 bottles for the price of 2
  • The manufacturer offers free shipping and a 60-day money-back guarantee


  • You can only buy it from the official website
  • Very popular product – You may have to go on waiting list during times of high customer demand

CLICK to see more about Yourbiololgy Gut+ including special deals

#2 – Biotics 8 (Best for Men)

three black pill bottles with orange lettering

CLICK to view Biotics 8 website for price and special offers

As far as the probiotic content goes, Biotics 8 is on an even footing with YourBiology Gut+. However, due to the abilities of the probiotic formula as a whole and the addition of a few additional ingredients, Biotics 8 is a much better option for men. And so it should be. This product is designed for men from the ground up.

Like YourBiology Gut+, Biotics 8 contains L. plantarum, which has scientifically proven credentials as a natural treatment for constipation and IBS.

Biotics 8 also provides Lactobacillus paracasei (L. paracasei) and Bifidobacterium longum (B. longum). Strains from both species have been proven to be effective for treating IBS-C and IBS-D (IBS with diarrhea). [8]

Some of the probiotics in the formula are known to boost testosterone production and male fertility. It also provides vitamin D, which plays a role in testosterone production too. Some research suggests taking vitamin D supplements can be a good way to alleviate the symptoms of IBS as well. [9]

Additionally, Biotics 8 provides enzymes that support the digestive enzymes that occur naturally in the stomach, helping to prevent or relieve digestive system problems.

This is unlikely to influence IBS but can aid nutrient absorption increasing the benefits available from food.

Like all the best probiotic supplements, Biotics 8 contains FOS. It has inulin as well. Inulin is another high-quality prebiotic fiber. It should work well alongside FOS, further helping to enhance probiotic activity.


  • Specially formulated for men
  • Shelf-stable
  • Provides well-researched probiotics
  • Contains 2 forms of prebiotic fiber
  • Boosts testosterone and male fertility
  • Provides many desirable health benefits
  • Free shipping
  • Possible to get 3 bottles for the price of 2
  • The manufacturer provides a 60-day money-back guarantee


  • You can only buy it from the official website
  • Possibility of stock shortages during times of high demand

CLICK to view the Biotic 8 website and see more infomation

#3 – Health Nutrition 40 Billion (Universal Constipation Relief)

white and green bottle

CLICK to view Health Nutrition website for price and special offers

Health Nutrition 40 Billion is equally suitable for both sexes and, like the top OTC alternatives to Linzess prescription drugs, it provides L. plantarum and FOS. It also contains B. lactis. Working together, these two powerful probiotics can be very effective in alleviating the symptoms of chronic idiopathic constipation and IBS-C. [4, 5, 7]

However, Health Nutrition 40 Billion is mainly marketed on its ability to boost immune function and improve digestive health. Due to its specialized nature and additional benefits, YourBiology Gut+ is a far superior choice for women. Likewise, Biotics 8 is a much better option for men.

Although the manufacturer of both these products usually does a good job of keeping up with customer demand, low stock issues are not unheard of.

If this happens, you may have to join a waiting list or search for an alternative product to use instead. If you find yourself in this predicament and don’t want to wait, Health Nutrition 40 Billion is a good alternative. It’s leaps and bounds ahead of all the other probiotic supplements we reviewed. That’s why we decided to include it as a standby option. Although it’s never going to be our top choice, it’s still the best of the rest.


  • Contains probiotics that can treat IBS-C
  • Includes FOS prebiotic fiber
  • Improves immune function and digestive health
  • The manufacturer provides a money-back guarantee


  • You can only buy it from the manufacturer’s website
  • Lack of discounts or other incentives to order multiple bottles

What Is Linzess and How Does It Work?

Linzess is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing fluid in the intestines and helping to speed up the movement of food through the gut.

This can improve stool texture and lessen constipation symptoms. Linzess acts locally in the intestine and is thought to work by calming pain-sensing nerves and accelerating bowel function. It stimulates the guanylate cyclase receptor, leading to an increase in fluid secretion and softening of stools.

Linzess Side Effects and Risks

Diarrhea is the most common side effect of Linzess. It can sometimes be severe and may be especially dangerous for children.

Other potential side effects include allergic reaction, bloating, gas, and stomach pain or discomfort. In some cases, Linzess may lead to weight loss due to diarrhea or weight gain due to bloating. Serious side effects are rare but may include eye symptoms such as sudden vision loss or blurred vision, as well as heart symptoms.

Drug interactions are another risk that bears consideration before and while using Linzess.

Other Popular Prescription Constipation Medications

In addition to Linzess, there are several other prescription drugs that can be used to treat constipation. These include Amitiza, Movantik, and Trulance. All three of these medications work by increasing the movement of food through the gut.

Amitiza works by stimulating certain receptors in the muscles of the gastrointestinal tract, which helps to relax the muscles and allow stool to pass more quickly.

Movantik works by blocking the activity of an enzyme called naloxegol, which is involved in slowing down digestion.

Trulance works by activating receptors on specific cells that help increase fluid secretion into the gut.

Unfortunately, like Linzess, all these alternative medications have the potential to cause allergic reactions and unpleasant side effects. Plus, as we mentioned previously, when you use laxative medications, there is a risk your bowels will become lazier, resulting in a greater dependence on laxative treatments. [3]

When considering prescription medications for constipation, it’s important to talk with your doctor about any medical conditions or medications you are taking to ensure the medication is safe for you.

Additionally, it’s important to understand the potential side effects of each medication so that you can make an informed decision about treatment.

Irritable Bowel Syndrome: A Look at the Different Types

Irritable Bowel Syndrome is a common gastrointestinal disorder that affects the large intestine (colon). It is a chronic condition characterized by recurring abdominal pain or discomfort, along with changes in bowel habits.

There are four sub-types:

1 – IBS with Constipation (IBS-C)

This type of IBS is associated with infrequent bowel movements and hard, lumpy stools.

People with IBS-C may experience abdominal discomfort or pain and a sense of incomplete evacuation.

2 – IBS with Diarrhea (IBS-D)

This type involves frequent, loose, and watery stools. Symptoms may include an urgent need to defecate, abdominal pain, and increased frequency of bowel movements.

3 – IBS with Mixed Bowel Habits (IBS-M)

This type encompasses both constipation and diarrhea, with alternating episodes of each. People with IBS-M may experience abdominal bloating, discomfort, and unpredictable bowel movements.

4 – IBS Unspecified (IBS-U)

Doctors use this category when their patients’ symptoms do not clearly fit into one of the other types mentioned above. IBS-U involves a combination of symptoms such as abdominal pain, bloating, and irregular bowel habits.

It’s important to be aware people with IBS may experience variations in their symptoms over time, and some may experience overlapping symptoms from different types.

Despite the difficulties in differentiating between them, when healthcare professionals are able to diagnose the specific type of IBS, it becomes easier to tailor appropriate treatment plans and IBS management strategies for their patients.

How Chronic Idiopathic Constipation Differs from IBS

Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome (IBS) are distinct gastrointestinal disorders. Each one has its own characteristics. Understanding the differences between CIC and IBS can help in accurate diagnosis and appropriate treatment. Here’s how they differ:

  1. Symptoms: CIC primarily involves infrequent bowel movements, typically fewer than three times a week, accompanied by difficulty passing stools. In contrast, IBS is characterized by abdominal pain or discomfort, along with changes in bowel habits such as diarrhea, constipation, or alternating between the two.
  2. Abdominal Discomfort: Although both conditions can cause abdominal discomfort, people with CIC often experience a sense of fullness or bloating due to delayed transit of stool in the colon. In IBS, abdominal pain may be crampy and a bowel movement may provide relief.
  3. Underlying Causes: The causes of CIC are not well understood, but it is considered a form of chronic constipation where abdominal pain is not a predominant symptom. On the other hand, IBS has a complex etiology involving factors like gut-brain axis dysfunction, visceral hypersensitivity, and altered gut microbiota.
  4. Diagnosis: CIC is diagnosed based on the presence of chronic constipation without an identifiable cause. IBS, however, is diagnosed based on specific criteria that include characteristic abdominal pain or discomfort along with changes in bowel habits.

Probiotic supplements can help with all these issues. However, many other conditions can present symptoms that are similar to those of IBS and CIC. If you suddenly develop these types of symptoms, it’s best to seek advice from a doctor or other suitably qualified healthcare provider.


What does Linzess do?

Linsezz is a drug class medication to treat chronic idiopathic constipation (CIC). It can only be obtained via prescription from a licensed healthcare professional.

How do you take Linzess?

Linzess is typically taken on an empty stomach, at least 30 minutes before the first meal of the day. It is important to follow the dosage instructions provided by your doctor and never exceed the maximum dose.

Is Linzess addictive?

No. This medication does not cause dependence or pose a risk of withdrawal symptoms.

Is Linzess a stimulant laxative?

No. Linzess is not a stimulant laxative.

Stimulant laxatives work by stimulating nerve endings in the intestinal wall, which increases muscle contractions and helps to speed up stool transit. Linzess works differently by targeting receptors in the gut that help increase the secretion of fluids and soften stools.

Can you make dietary changes instead of using Linzess?

Some people successfully manage IBS and CIC by avoiding their trigger foods. However, discovering problem foods can be time-consuming. Keeping a food diary may help speed up the process but good probiotic supplements can provide faster relief along with other desirable benefits such as higher energy levels and better immunity.

Can you take Linzess with other medications?

Yes, Linzess can be taken safely with most other medications. However, it is important to inform your healthcare provider about any medications or supplements you are taking before starting a new medication. This includes prescription and over-the-counter drugs as well as vitamins and herbal products. Certain options may interact badly.

Do natural alternatives to Linzess cause side effects?

Most natural alternatives to Linzess are safe and well-tolerated by most people. However, it is important to check the ingredients carefully as some may cause unwanted side effects such as diarrhea or abdominal cramps.

Natural remedies, such as Aloe vera and Senna, may also impair normal bowel activity after prolonged use. Probiotic supplements do not present this problem.

However, in rare cases, users may have mild gastrointestinal side effects such as bloating and discomfort. Fortunately, this type of response is typically short-lived and settles down after the body becomes accustomed to the changes in the gut microbiome.

What are probiotics?

Probiotics are live microorganisms, such as bacteria or yeasts, that are beneficial for our digestive system. They can help regulate gut flora and promote a healthy balance of bacteria in the gut.

How long does it take for probiotics to show results?

The time it takes for probiotics to show noticeable effects can vary from person to person. Some people may experience improvements within a few days, while others may require several weeks of consistent use.

Results may also depend on the specific probiotic strain and factors such as genetics and lifestyle.

Best Alternative to Linzess Concluding Thoughts

For people with IBS and CIC, Linzess can be a valuable tool in helping to manage symptoms. However, it is important to understand that there are plenty of natural alternatives available as well.

Probiotic supplements stand out as being the best option. Certain probiotic species and strains can offer significant relief from abdominal discomfort, bloating, and irregular bowel habits by supporting the gut microbiome.

Dietary supplements such as Yourbiology Gut+ provide probiotic bacteria also deliver many additional health benefits that can further improve quality of life and will not make the bowel lazier and more dependent on help. However, as with all dietary supplements, probiotic products work best when you use them in combination with healthy lifestyle habits.

Research Sources

  1. Probiotics in Irritable Bowel Syndrome: A Review Article:
  2. Adverse Effects of Laxatives:
  3. Laxative Use: What to Know:
  4. Clinical Trial: Lactobacillus Plantarum 299V (Dsm 9843) Improves Symptoms of Irritable Bowel Syndrome:
  5. Lactobacillus Plantarum lp3a Improves Functional Constipation: Evidence From a Human Randomized Clinical Trial and Animal Model:
  6. The Effect of Probiotics on Functional Constipation in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials:
  7. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review:
  8. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study:
  9. Effects of Vitamin D Supplementation in Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial:

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