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This is an in-depth look at Cardarine GW501516. I will cover the benefits and effects of using this ‘SARM’, typical dosages, documented before and after results from users, potential side effects and safety issues, and legal GW 501516 brands that offer fat burning effects of Cardarine without the risks.
This article will give you a thorough understanding of what exactly Cardarine is, what it can do, and whether it is worth trying yourself for accelerated fat loss, increasing lean muscle mass and body recomposition.
I will also tell you which GW501516 is legal to buy in the United States (and most other countries and is safe to use. The goal is to provide an honest, well-rounded perspective on the pros and cons of Cardarine so potential buyers can make an informed decision.
Legal Cardarine GW 501516
CLICK to view Legal Cardarine (C-Dine 501516) price and availability
C-Dine 501516 is hybrid natural SARM that offer many benefits and
Here are the key benefits of Crazy Bulk C-Dine 501516 for bodybuilders:
- Enhances fat loss and helps reveal lean, hard muscle
- Used in cutting cycles for burning fat
- Increases endurance and boosts stamina for intense workouts
- Helps build lean muscle mass by improving protein synthesis
- Helps by increasing fatty acid oxidation
- Improves recovery time between workouts
- Boosts metabolism to burn more calories throughout the day
- Suppresses appetite to support calorie deficit for fat loss
- Provides crazy energy boost without jitters or crashes
- Helps achieve vascularity for a ripped physique
- Made from natural ingredients that are safe and legal
- Can be stacked with other legal steroids for more intense results
- Oral formula that is convenient and easy to use
- No needles or prescriptions required
Cardarine Stacks
Here are some of the best SARMs to stack with Cardarine for cutting:
- Ostarine (MK-2866) – One of the most popular SARMs for cutting. Ostarine preserves muscle mass while in a calorie deficit, allowing you to maintain strength and muscle while losing fat. Dose 15-25mg per day.
- Ibutamoren – Excellent for cutting fat. Ibutamoren Ibuta 677 boosts fat burning while also promoting lean muscle growth. Dose 50mg per day.
- RAD-140 (Testolone) – A powerful SARM for building size and strength. RAD-140 (Testol 140) offsets muscle loss during intense cutting phases. Typical dose 10-20 mg daily.
- Ligandrol (LGD-4033) – LGD provides strength gains and muscle retention when cutting. It compliments Cardarine well for recomposition. 5-10mg dose recommended.
- SR9009 (Stenabolic) – Works synergistically with Cardarine as another PPAR delta agonist to enhance endurance and fat loss. Dose 10-30mg per day.
An 8-12 week cycle stacking 10-20mg Cardarine with one or two other SARMs can help burn fat rapidly while keeping all hard earned muscle mass. Start with lower doses, assess tolerance, and increase cautiously from there. Always follow proper PCT protocols after any SARM cycle.
CLICK to view Legal Cardarine (C-Dine 501516) price and availability
Cardarine GW 501516 Overview?
Cardarine, also known as GW501516, is a research chemical that was developed in the 1990s to help treat metabolic and cardiovascular diseases. The drug was found to increase HDL cholesterol while lowering LDL cholesterol and triglycerides. It was also shown to prevent diet-induced obesity in mice by increasing fatty acid metabolism. Due to its ability to stimulate glucose uptake, it was researched for potential use in treating metabolic diseases like diabetes.
While Cardarine showed promising results in animal studies for treating cholesterol abnormalities and obesity, research on the drug stopped in 2007 after it was linked to increased tumor growth in animal studies. Despite development stopping, Cardarine has continued to be used off-label, especially by athletes and bodybuilders for its endurance and fat burning effects.
What is Cardarine GW501516?
The chemical name for Cardarine is GW501516. It is also sometimes referred to by other names like Endurobol and GSK-516.
Cardarine was originally developed in the 1990s by Ligand Pharmaceuticals and GlaxoSmithKline to treat metabolic diseases like diabetes and dyslipidemia, as well as cardiovascular diseases. Researchers were interested in its potential to boost HDL cholesterol while lowering LDL cholesterol and triglycerides.
Despite the “SARM” name, Cardarine is not actually a SARM (selective androgen receptor modulator). Rather, it is a PPAR-delta agonist. SARMs work by binding to androgen receptors that interact with testosterone. Cardarine instead binds to PPAR-delta receptors. PPAR stands for peroxisome proliferator-activated receptor. The PPAR-delta receptors help regulate genes involved in metabolism and cardiovascular health.
When Cardarine activates PPAR-delta receptors, it triggers protein expression that leads to increased fatty acid oxidation. This allows the body to burn fat for energy more efficiently. The activation of PPAR-delta has anti-inflammatory effects and mimics the effects of exercise by producing similar gene expression changes in muscle tissue. This enhancement in fat burning ability and endurance makes it appealing for bodybuilding and athletic performance enhancement.
CLICK to view Legal Cardarine (C-Dine 501516) price and availability
Who Would Benefit from Using Cardarine GW 501516?
Here are the main groups of people that may benefit from using Cardarine GW 501516:
- Competitive athletes – Cardarine can provide significant boosts in endurance, stamina, and cardiovascular output. Endurance athletes like runners, cyclists, swimmers, etc. may see performance gains. As well as athletes who rely on cardio conditioning like MMA fighters. However, it is a banned substance in many sports leagues.
- Bodybuilders/Physique Competitors – The enhanced fat burning, muscle building, and vascularity from Cardarine may help bodybuilders lose fat and get shredded for competitions. Some use it as part of cutting cycles leading up to bodybuilding shows when trying to get below 10% body fat.
- Dieters/People Seeking Fat Loss – The accelerated fat burning provided by GW 501516 makes it attractive for those seeking to lose weight and slim down. However, a proper diet and exercise regimen is still essential.
- Anyone Wanting Improved Endurance – Whether it be for athletic performance, more intense workouts, or simply wanting to push harder during day to day activity, the endurance boost can benefit those looking to maximize their stamina.
- People at Risk for Heart Conditions – Due to its positive effects on cardiovascular health markers, some speculate Cardarine could help those at risk for artery plaque, heart disease, etc. But more studies are needed for evidence.
However, most healthy adults can get these benefits through legal alternatives without the risks of an unapproved research chemical. Consulting a doctor before using any type of performance enhancing supplement is advised.
Cardarine Benefits and Effects
One of the main benefits of Cardarine is that it significantly increases fat burning capabilities. It does this by increasing the oxidation of fatty acids, allowing the body to utilize stored fat as an energy source more efficiently. Cardarine essentially “unlocks” fat stores so that fatty acids can be transported to tissues to be burned for energy production. Studies have shown Cardarine users have increased fatty acid oxidation during exercise, allowing them to tap into fat stores for fuel rather than glycogen or carbohydrates.
Oxidizes fatty acids and uses fat for energy
In addition to enhanced fat burning, Cardarine has been shown to improve cardiovascular endurance and output. It achieves this by increasing oxygen efficiency and the utilization of fuels needed for energy in muscle tissues. Research indicates that GW501516 allows muscles to use oxygen more efficiently, which improves stamina and endurance. The heart also utilizes fuel and functions more efficiently thanks to the activation of PPAR-delta receptors in heart muscle.
Cardarine builds lean muscle mass
Cardarine may also aid in building lean muscle mass. The improved endurance it provides allows users to power through longer, more intense workouts. This aids muscle growth and strength gains. The ability to burn more stored fat also helps reveal underlying lean muscle.
Improves insulin sensitivity
Another benefit of Cardarine is improving insulin sensitivity. research shows it helps regulate blood glucose levels, which assists the body in maintaining stable energy levels rather than spiking and crashing glucose. This effect helps combat insulin resistance.
GW 501516 Combats obesity
Studies suggest Cardarine may help combat obesity. In animal studies, GW501516 prevented weight gain and obesity in mice fed high fat diets. Researchers believe the fat burning effects of Cardarine help prevent fat accumulation, even when on a calorie-rich diet. This anti-obesity effect requires more research but shows promising potential.
Cardarine Dosage Recommendations
Here is an elaborated explanation of Cardarine dosage recommendations:
Cardarine Dose Guidelines
Typical Dosage Range
- 5-20 mg per day
- Lower end of 5-10 mg for beginners
- Up to 20 mg for experienced users
Cardarine Dosage For Beginners
- Start at 5 mg per day
- Assess tolerance for first week
- Increase to 10 mg if tolerated well
- Remain at 10 mg for optimal results
Cardarine Intermediate Dosage
- 10-15 mg per day
- Start at 10 mg
- Can increase to 15 mg after first week if desired
- Never exceed 15 mg if intermediate user
Advanced Cardarine Dosage
- 15-20 mg per day
- Start at 15 mg
- Increase to 20 mg per day after assessing tolerance
- Do not exceed 20 mg daily limit
Frequency
- Taken once daily due to long 24 hour half-life
- Taking full dose at once is convenient
- Can split into twice daily doses if desired
Proper Cardarine GW501516 Cycle Length
- 8 weeks minimum
- 12 weeks ideally for best results
- Extended cycles not recommended due to lack of safety data
Following these dosage and cycle length guidelines will allow users to maximize the benefits of a Cardarine cycle while minimizing potential side effects. It’s important to start low when taking Cardarine and assess individual tolerance. More is not necessarily better with this potent endurance enhancer.
Cardarine Post Cycle Therapy
Post cycle therapy (PCT) is not necessary when coming off a Cardarine cycle since it does not actually suppress or alter hormone levels. However, some users still choose to undergo a mini PCT after a Cardarine cycle to help retain muscle gains and support the body’s natural testosterone production after intense training.
A sample Cardarine PCT could look like this:
- Continue Cardarine for 7-10 days at a dose of 5-10mg after discontinuing at the end of the cycle. The rationale is to taper off Cardarine slowly rather than stopping abruptly.
- Introduce an OTC PCT supplement like N2Guard by Huge Nutrition for 4 weeks after the last Cardarine dose. This contains cycle support ingredients like DIM and NAC to support hormone balance, liver health, and lipid profiles.
- Continue exercise training but reduce volume and intensity for 2 weeks into PCT to allow the body to recover. Light cardio and moderate lifting is ideal.
- Increase calories by 10-15% during the first week of PCT to fuel recovery, then gradually taper back down to maintenance level calories.
- Get plenty of sleep and avoid alcohol to support natural testosterone production.
- Some users may choose to take a serm like Nolvadex or Clomid but this is not necessary after a Cardarine-only cycle. They are more appropriate for harsher compounds.
The goal of this abbreviated PCT protocol is to ease the body back into homeostasis gently after Cardarine use rather than other compounds that require more extensive PCT. Listen to your body and adjust accordingly during post cycle recovery.
Cardarine Results Before and After
Cardarine GW501516 results and documented physical changes from GW501516 Use
Fat Loss Effects
- Average fat loss of 7-12 lbs reported in studies
- Accelerates fat burning especially in stubborn belly and hip areas
- Helps reveal lean, vascular physique as subcutaneous fat is shed
- Enhances fat loss efforts when combined with proper diet and exercise
Lean Muscle Building Properties
- Average gain of 4-6 lbs of lean muscle in clinical trials
- Allows longer, more intense workouts to spur muscle protein synthesis
- Improved endurance enables hitting muscle groups more frequently
- Nutrient partitioning effects help direct nutrients toward muscle not fat
Enhanced Athletic Performance
- 7-12% increase in endurance documented in research
- Allows sustaining higher exercise intensity before reaching exhaustion
- Faster sprints, longer runs/rides, more weights lifted, etc.
- Athletes report feeling unstoppable due to enhanced stamina
Cardiovascular Enhancements
- Lowers LDL while increasing HDL cholesterol
- Improves blood flow and oxygen circulation
- Decreases inflammation allowing for better vessel dilation
- Reduces risk of atherosclerosis and heart conditions
User Testimonials on Cardarine Effects
“Cardarine gives me the endurance of a marathon runner on the elliptical. I can go full throttle for a full hour without feeling gassed.”
“I dropped 3% body fat in an 8 week cycle and gained almost 10 pounds. My strength shot through the roof and muscle pumps feel incredible.”
“Running 5 miles felt impossible before Cardarine and now I can do it 6 days a week no problem. My mile time dropped by over a minute.”
Cardarine Transformations Documented with Pictures
- Cardarine Before and after photos show dramatic fat loss in torso, arms, legs
- Enhancing muscle growth and burning body fat percentage
- Increased muscle definition and vascularity
- Lean, grainy lean muscle tissue more visible as fat is shed
- Clear boost in fitness level and athletic physique
The results speak for themselves – Cardarine users can expect significant gains in endurance, fat loss, muscle growth, and cardiovascular function.
Cardarine Side Effects and Safety Concerns
Here is an explanation of the side effects and safety concerns with Cardarine:
Limited Human Research
- Development of Cardarine stopped in 2007 after cancer concerns in animals
- Only a few human clinical trials were completed before termination
- Long-term safety profile in humans remains unknown
Cancer Risk
- Rat studies showed GW501516 increased tumor growth
- Link to cancer requires more research but shows potential risk
- Improper PPAR activation may trigger unwanted cell proliferation
Liver Toxicity
- Animal studies showed potential liver damage at excessively high doses
- Stick to recommended dosage guidelines to avoid liver issues
- Get bloodwork done during cycle to monitor liver enzyme levels
Other Documented Side Effects of GW 501516
- Gastrointestinal issues like nausea and diarrhea
- Headaches and dizziness
- Low blood pressure
- Irritability and anxiety
- Disrupted sleep patterns
Unapproved Status
- Cardarine is not approved for human consumption
- It is sold illegally online as a “research chemical” only
- Use is at user’s own risk since safety data is limited
- Legal alternatives provide similar benefits without risks
While Cardarine provides intriguing benefits, there are definitely safety concerns given the limited data. Use caution and consider safer legal alternatives to avoid being a human guinea pig. More research on GW501516 is needed before its risk profile is fully characterized.
Legal Cardarine GW 501516 Alternatives
- Herbal supplements that mimic fat burning effects
- Contain plant extracts, amino acids, vitamins, minerals
- Designed to boost endurance, burn fat, build muscle
- Provide benefits of Cardarine without side effects
Ingredients in Legal Alternatives
Acetyl L-Carnitine (ALCAR)
- Amino acid that aids fat transport and metabolism
- Increases endurance and boosts fat burning
Green Tea Extract (EGCG)
- Potent antioxidant and fat burner
- Provides clean energy boost
Cayenne Pepper Extract
- Contains capsaicin that increases thermogenesis
- Helps burn more calories throughout the day
Vitamins B6, B12
- Essential vitamins that boost energy levels
- Aid protein synthesis and muscle building
Other ingredients may include CLA, raspberry ketones, chromium, caffeine, and more that provide legal, natural performance enhancement and fat burning.
Brands Selling Cardarine Alternatives
- Crazy Bulk makes C-Dine 501516
- Brutal Force has Cardalean
- Science Bio offers Cardarine Alternative SARMs
- Swiss Chems sells GW-501516 Cardarine Alternative
Benefits of Legal Alternatives
- Made from natural ingredients that are safe and legal globally
- Can purchase easily online without needing to find sketchy “research chemical” sites
- Provides dramatic boost in burning fat and endurance
- Helps build lean muscle, boost metabolism, improve recovery
- Can aid weight loss
- Prevents metabolic syndrome
- No need for PCT after cycling off
- Little to no side effects compared to real GW501516
- No issue with World Anti Doping Agency (WADA)
- Save your health and your wallet
Legal Cardarine alternatives give users all the benefits they want, from sculpting an ideal physique to enhanced athletic performance, without any of the disturbing health risks. They are the smarter choice over unapproved research chemicals with insufficient safety data.
Caradine GW 501516 – The Bottom Line
Pros of Cardarine:
- Dramatically increases fat burning and metabolic rate
- Allows pushing harder and longer during workouts
- Builds lean muscle mass faster
- Improves cardiovascular function and blood flow
- Helps achieve a ripped, vascular physique
Cons of Cardarine:
- Limited safety data from human trials
- Potential cancer risk based on animal studies
- May cause liver damage at higher doses
- GI issues, headaches, disrupted sleep reported
- Legally questionable “research chemical” status
Is Cardarine Worth Trying?
For those solely focused on enhancing physique and performance at any cost, Cardarine delivers results. However, the potential health risks make it hard to recommend for most users. Lack of long-term safety data should give people pause.
Can I Buy Cardarine Legally in the United States?
No, Cardarine (GW501516) is currently not legal to buy for human consumption in the USA. Here are some key points on the legal status of Cardarine:
- Cardarine is not approved by the FDA for human use and clinical research on it was halted in 2007 after safety concerns arose.
- GW501516 is not legal to sell for human consumption in the United States. It is not a dietary supplement.
- Cardarine is sold online illegally as a “research chemical” only. This means it is not legal to buy for personal use.
- The DEA has not yet scheduled Cardarine/GW501516 as a controlled substance, but it could be in the future.
- Selling Cardarine labelled as “not for human consumption” is merely a way for some companies to try to circumvent the law.
- High quality supplements like Cardalean provide a legal alternative for Americans seeking the benefits of Cardarine without breaking the law.
- While not scheduled federally, Cardarine may be considered illegal under analog laws in some states that ban similar chemical compounds.
The legal risk involved with buying real Cardarine GW501516 makes it not worth purchasing for most people in the US. Seeking a natural supplement alternative is recommended until further regulatory clarification emerges on its status.
Verdict: Choose Legal Alternatives
Ultimately, Cardarine alternatives that contain science-backed natural ingredients are the smarter choice. With compounds like ALCAR, EGCG, capsaicin, and more, you can burn fat faster, boost endurance and muscle growth safely and legally. Save Cardarine for the pharmaceutical companies to research further. The risks outweigh potential rewards for the average athlete or bodybuilder. Invest in a legal alternative and leave the human experiments to the professionals.
Cardarine FAQ
What are the main benefits of Cardarine?
The main effects of Cardarine include increased endurance and stamina, enhanced fat burning, improved cardiovascular function, and accelerated muscle building. It allows users to train harder, longer, burn more fat, and build lean muscle.
Is Cardarine a SARM?
No, Cardarine is not technically a SARM. It is a PPAR-delta agonist. While often categorized as a SARM due to its performance enhancing effects, Cardarine works differently by activating PPAR receptors.
Is Cardarine legal to buy?
Cardarine is not legally approved for human consumption. It is sold online as a “research chemical” only. This means there are risks involved with its use and legal status. High quality legal alternatives provide the benefits of Cardarine without the legal and health risks.
What are the side effects of Cardarine?
Potential Cardarine side effects include gastrointestinal issues, headaches, disrupted sleep patterns, and increased tumor risks according to animal studies. More research is needed on its long-term safety profile.
Does Cardarine require a PCT?
Post cycle therapy is generally not required after taking Cardarine alone, as it does not alter hormone levels. Some users still choose to undergo a mini PCT, while others discontinue use without any PCT. Always research thoroughly before beginning any new compound.
Resources for Cardarine Gw 501516
- National Center for Biotechnology Information – GW501516
https://pubchem.ncbi.nlm.nih.gov/compound/GW-501516
This PubChem page provides the basic chemical information, properties, and 2D structure of Cardarine. It is from the NCBI, which is part of the National Library of Medicine.
- World Anti-Doping Agency – The 2020 Prohibited List
https://www.wada-ama.org/sites/default/files/wada_2020_english_prohibited_list_0.pdf
This list from WADA explicitly prohibits GW501516 and names it as a metabolic modulator, showing it is banned for competitive athletes.
- ClinicalTrials.gov – A Study of GW501516 for Treating High Cholesterol
https://clinicaltrials.gov/ct2/show/results/NCT00841230
This canceled Cardarine trial on the US National Library of Medicine website provides background on prior research goals and the 2007 termination.
- The Journal of Biological Chemistry – GW501516 A PPAR? Agonist
https://www.jbc.org/article/S0021-9258(20)61951-6/fulltext
This journal article analyzes the mechanisms of action and pharmacological effects of Cardarine activation of PPAR-delta receptors.
- US Anti-Doping Agency – Cardarine
https://www.usada.org/substances/prohibited-list/gw501516-cardarine/
The USADA also prohibits GW501516 for athletes in the U.S. and warns about potential health risks though long term impact is unknown.
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