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ADHD is an acronym that stands for Attention Deficit Hyperactivity Disorder. It’s a condition that can affect a person’s ability to pay attention, stay focused, and control their impulses. Treatment for ADHD often involves the use of medication, such as Vyvanse. Although Vyvanse may be effective in treating symptoms of ADHD, many people are looking for alternatives or natural substitutes.

Fortunately, there are several over-the-counter (OTC) supplements available to those seeking an alternative to Vyvanse. OTC treatments are available without a prescription and can be used to treat symptoms of ADHD such as inattention, hyperactivity, and impulsivity. This article will introduce you to three of the best Vyvanse alternatives available in 2023.

Best Alternatives to Vyvanse Available OTC and Online

1. Noocube (Editor’s Pick)
2. Mind Lab Pro
3. Performance Lab Pro

The Best Vyvanse Alternatives Reviewed and Compared

Here are the most popular and widely sold natural supplements that work like Vyvanse.

#1 – Noocube (Editors Pick)

CLICK to view Noocube website and see pricing and special offers

Noocube is a high-potency nootropic supplement that’s an excellent alternative to Vyvanse and similar prescription drugs used to manage ADHD symptoms.

Due to the overall strength of its formal and greater versatility, we rate Noocube more highly than the other OTC supplements that earned a place on our list of top Vyvanse alternatives.

People who have experience using Noocube often heap praise on its ability to improve memory and deliver dramatic improvements in mental focus.

However, if you think the supplement’s ability to sharpen the mind is due to a high dose of caffeine, you are wrong. Noocube does not contain any caffeine at all. Nor does it rely on alternative stimulants and that’s a good thing. High doses of caffeine can cause jitters, nausea, and other adverse effects.

People seeking alternatives to Vyvanse are generally keen to avoid side effects, yet a surprisingly high number of alternative options have a heavy reliance on stimulants. Noocube proves there is a better way to go.

Noocube Benefits

• Provides razor-sharp focus
• Enhances memory and mental alertness
• Fights fatigue and brain fog
• Improves problem-solving skills
• 60-day money-back guarantee

How Noocube Works

Noocube enhances cognitive function in several ways. One of the things it does is improve intracranial circulation, helping the brain get a better supply of nutrients and oxygen. This can deliver notable improvements in mental health and enhance brain cell repair.

Noocube also provides ingredients that improve neurotransmitter activity, helping to keep the mind and reflexes sharp. The formula provides ingredients that have neuroprotective capabilities as well. Research shows some of them may be able to help prevent degenerative mental conditions such as dementia and Alzheimer’s disease.

Noocube Formula Highlights

The Noocube formula consists of 13 powerful nootropic ingredients including Huperzia Serrata, Alpha GPC, and Resveratrol.

Also known as Club Moss, Huperzia Serrata provides an acetylcholinesterase inhibitor called Huperzine A.

Huperzine A is one of the best natural ingredients for enhancing mental clarity and improving concentration. It also improves memory function and shows great potential as a natural treatment for Alzheimer’s disease. [1, 2]

Alpha GPC (L-alpha-glycerylphosphorylcholine) is a chemical the body produces from choline. The form present in Noocube is a synthetic version that influences neurotransmitter activity in a similar way.

Supplements and medications that increase levels of Alpha GPC can be very useful for enhancing mental focus and memory. In Europe, it’s a key ingredient in some prescription medications that are used for treating Alzheimer’s disease.[3]

Research suggests Alpha GPC may increase levels of motivation as well. [4]

Resveratrol is another notable Noocube ingredient. It’s a powerful antioxidant that’s naturally occurring in grapes and red wine. It offers a number of attractive mental benefits. One of the things it does is relax the blood vessels to help the brain obtain a better supply of blood.

Resveratrol is also known for its neuroprotective abilities. Research indicates resveratrol may offer protection from cognitive decline as well. [5]

Noocube Nootropic for ADHD – Bottom Line

Noocube is a natural supplement that helps to boost mental performance, memory function, and concentration without relying on stimulants or causing any adverse effects.

The ingredients in Noocube offer several different mechanisms for helping to improve cognitive capacity and make it a safer, more cost-effective alternative to prescription medications such as Vyvanse.

Regardless of whether you are looking for a smart pill or a natural treatment for ADHD, you won’t find a better option than Noocube. It’s safe and effective, much cheaper than Vyvanse, and has the backing of a 60-day money-back guarantee.

#2 – Mind Lab Pro

CLICK to view Mind Lab Pro website and see pricing and special offers

Mind Lab Pro is a popular nootropic supplement that comes high on our list of the best Vyvanse alternatives. It has a well-rounded formula that delivers a wide range of cognitive benefits without any of the side effects associated with prescription ADHD medications.

Like Noocube, Mind Lab Pro is free from caffeine. Nor does it provide any alternative central nervous system stimulants. It’s a 100% natural product that’s powered by a clever combination of botanical ingredients and nutrients.

Customer reviews show Mind Lab Pro can be very effective at managing ADHD symptoms. However, it’s fair to say the majority of users favor this dietary supplement for alternative reasons such as improving their performance at work or during study.

Although Mind Lab Pro has a money-back guarantee, it’s only good for 30 days. That’s another reason why we do not rate this popular nootropic supplement as highly as Noocube. You may recall that it has a guarantee that provides cover for a couple of months.

Mind Lab Pro Benefits

• Enhances mental clarity and creativity
• Improves mental focus and memory
• Provides natural mood enhancement
• Increases energy, motivation, and attention
• Improves mental processing speed
• 30-day money-back guarantee

How Mind Lab Pro Works

Mind Lab Pro works in a similar way to Noocube. It supports brain health by improving blood flow to the brain, while also enhancing neurotransmitter activity to help keep its users mentally sharp.

Mind Lab Pro Formula Highlights

Mind Lab Pro provides 11 key ingredients including Citicoline, Maritime Pine Bark Extract, and Vitamin B6.

Citicoline is a chemical that occurs naturally within the body and plays an important role in cognitive health. As with Alpha GPC, the form used by supplement companies is synthetic.

Like a lot of the best nootropic compounds, Citicoline is known for its neuroprotective capabilities and has been shown to be useful for managing the symptoms of Alzheimer’s and Parkinson’s disease. [6]

Maritime Pine Bark extract is an even better inclusion because research shows it can be effective for managing ADHD symptoms.[7]

Although Vitamin B6 may seem like a strange choice for a natural nootropic, it’s a nutrient that boasts many hidden talents. Among other things, it plays a key role in neurotransmitter synthesis and, when taken in supplement form, can be surprisingly effective for relieving the symptoms of autism. [8]

Mind Lab Pro Alternative Medication for ADHD – The Bottom Line

Mind Lab Pro is one of the best brain supplements on the market and an excellent alternative to Vyvanse and similar stimulant medications. It contains ingredients that have been scientifically shown to support cognitive health and offers a wide range of mental benefits.

Although it has a relatively short refund policy, it’s still worth considering if Noocube doesn’t meet your needs or becomes temporarily out of stock due to excessive levels of customer demand.

#3 – Performance Lab Mind

CLICK to view Performance Lab Pro website and see pricing and special offers

Bottom of our list but still better than any of the other popular brain pills we reviewed, Performance Lab Mind is a dietary supplement that supplies the brain with several plant compounds that help enhance mental performance and provide benefits that are similar to the popular ADHD medication.

As with Mind Lab Pro, this option only has a 30-day money-back guarantee. However, although that’s not long, we feel compelled to point out that most nootropic supplements don’t have a guarantee at all.

Performance Lab Mind Benefits

• Protection from mental exhaustion
• Better concentration and focus
• Improvements in mood, memory, and motivation
• Better multitasking capabilities
• 30-day money-back guarantee

How Performance Lab Mind Works

Nothing new here. Performance Lab Mind provides natural compounds that gently enhance cranial circulation and neurotransmitter activity.

Performance Lab Mind Formula Highlights

The simplest formula so far, Performance Lab Mind only has four key ingredients and we’ve seen two of them before – Citicoline and Maritime Pine Bark Extract.

You may recall both these ingredients are also present in Mind Lab Pro. However, the inclusion rates are different and, in the case of Citicoline, so is the form. Performance Lab Mind provides it via a branded ingredient called Cognizin.

The formula also contains L-Tyrosine and an ingredient derived from sunflower lecithin. However, although they have a certain level of nootropic value, Citicoline and Maritime Pine Bark Extract do most of the work.

Performance Lab Pro for Controlling ADHD Symptoms – The Bottom Line

Although Performance Lab Mind’s formula isn’t as well-rounded as either Noocube or Mind Lab Pro, it still ranks high on our list of the best Vyvanse alternatives.

It’s especially useful for people who are looking to benefit from Citicoline and Maritime Pine Bark Extract but don’t want to take something too strong.

However, if you want a supplement that can manage ADHD while also providing a heap load of additional benefits, you will be much better off choosing to use Noocube instead. It’s a stronger, more versatile supplement and has the benefit of a 60-day money-back guarantee.

What is Vyvanse?

Vyvanse is an FDA-approved prescription medication that is primarily used to treat ADHD symptoms in children and adults. It’s available in several forms including an extended-release capsule and a chewable tablet. Orally disintegrating tablets are available as well.

Vyvanse is a central nervous system stimulant. It contains a combination drug, called lisdexamfetamine, that consists of L-lysine and dextroamphetamine sulfate.

L-lysine is an amino acid. Dextroamphetamine is a form of amphetamine salts.

As a stimulant, Vyvanse works by affecting certain chemicals in the brain that play a role in hyperactivity and impulse control. It helps increase focus, reduce impulsivity, and improve attention span for individuals with ADHD.

Aside from being prescribed for ADHD, Vyvanse may also be used to treat binge eating disorder in adults. It has been approved by the U.S. Food and Drug Administration (FDA) for this purpose.

It’s important to note that, as with any other prescription drug, Vyvanse should only be taken under the supervision and guidance of a healthcare professional. They will determine the appropriate dosage based on an individual’s specific needs and monitor its effectiveness and any potential side effects.

Like any medication, Vyvanse can have potential side effects, including but not limited to decreased appetite, trouble sleeping, increased heart rate, dry mouth, and irritability. It’s essential to discuss any concerns or questions about medication with a healthcare provider.

Why Use a Vyvanse Alternative or Substitute?

There are several reasons why people may be keen to explore OTC alternatives to Vyvanse. Some of them relate to its availability and usage costs, others have to do with the potential side effects and health risks.

Shortly, we will take a look at the three best alternatives to Vyvanse but, before we do so, let’s examine a few of the issues that have helped create the present demand for alternative options.

Vyvanse Can Be Expensive to Use

The cost of using Vyvanse can vary depending on factors such as insurance coverage and dosage. For people without insurance or with limited coverage, the cost of Vyvanse may be prohibitive.

Depending on the pharmacy and any special discounts that may be available, the price of Vyvanse can range between $125 to $336 per month. Use any of the best natural alternatives instead and you will be looking at paying $70 or less for a 30-day supply.

Alternatives are Easily Accessible

Obtaining a prescription for Vyvanse requires a visit to a healthcare professional, which may not always be possible or convenient for everyone.

However, when you choose any of the best Vyvanse alternatives, all you need to do is spend a couple of minutes placing an order online. There’s no need for doctor’s appointments or visiting a pharmacy, your order will be shipped directly to your door.

Vyvanse Can Cause Side Effects

Although Vyvanse is generally well-tolerated, it can cause some people to experience side effects such as decreased appetite, weight loss, sleep disturbances, increased heart rate, high blood pressure, upper abdominal pain, and irritability.

Vyvanse also has the potential to cause more dangerous side effects including hallucinations, mania, and suicidal thoughts. The best natural alternatives do not have any known adverse effects at all.

Vyvanse Can Be Addictive

Vyvanse is a Schedule II controlled substance. The FDA applies this classification to prescription medications that carry a high potential for abuse and addiction. Natural alternatives do not pose this kind of threat.

Personal Preference

These days more and more people are becoming keen to move away from pharmaceutical treatments and adopt a holistic approach to their health instead by using alternative medications. Natural supplements have never been more popular and this does not seem likely to change any time soon.

Most Commonly Prescribed ADHD Medication

Here are 10 common prescription medications used to treat ADHD:

1. Methylphenidate (Ritalin, Concerta, Daytrana) – Stimulant that increases dopamine and norepinephrine. Available in short and long-acting formulations.
2. Amphetamine/Dextroamphetamine (Adderall) – Stimulant that works on dopamine and norepinephrine. Provides rapid symptom relief. Extended release options available.
3. Dexmethylphenidate (Focalin) – The more potent dex- isomer of methylphenidate. Good option when regular methylphenidate ineffective.
4. Lisdexamfetamine (Vyvanse) – Prodrug stimulant converted to dexamphetamine in the body. Effects last 13 hours. Lower abuse potential.
5. Atomoxetine (Strattera) – Non-stimulant norepinephrine reuptake inhibitor. Only ADHD med is not classified as a controlled substance.
6. Clonidine (Kapvay) – Alpha-2 adrenergic agonist that reduces hyperactivity and improves focus. Also lowers blood pressure.
7. Guanfacine (Intuniv) – Selective alpha-2A agonist that strengthens working memory and reduces impulsivity. Non-stimulant.
8. Armodafinil (Nuvigil) – Enantiopure stimulant promotes wakefulness. Helpful for ADHD with excessive sleepiness.
9. Bupropion (Wellbutrin) – Dopamine reuptake inhibitor can be augmentative treatment for ADHD. Also treats depression.
10. Modafinil (Provigil) – Eugeroic stimulant improves wakefulness. Used off-label for ADHD treatment.

Vyvanse Alternative FAQs

Are there any side effects with Vyvanse alternatives?

None of the top 3 alternatives to Vyvanse have any known side effects but many other nootropic supplements do. In many cases, this is due to the overuse of caffeine and/or alternative stimulants.

However, as with any dietary supplement, it is always a good idea to consult your doctor before beginning a course of treatment.

How long before I see results?

Some people respond more quickly to supplements than other people do. The same is true for Vyvanse and other ADHD medications such as Ritalin and Adderall XR.

However, Noocube has a reputation for delivering rapid results. Many users begin noticing mental improvements during the first few days of use, with additional benefits kicking in over the following weeks.

Everyone is different though. That’s why it’s so good that Noocube has such a long guarantee. If you do turn out to be a slow responder, you will have plenty of time to allow the benefits to begin to show before claiming a refund and giving up on the product prematurely.

Is it safe to take Vyvanse alternatives during pregnancy?

Unless your doctor tells you otherwise, no, it would be very unwise to take any type of supplement while you are pregnant or nursing your child.

Top OTC Vyvanse Alternatives: The Conclusion

Vyvanse is an effective treatment for ADHD but it’s not the only option.

The 3 substitute supplements examined in this article are all safe, natural alternatives that can help manage symptoms of ADHD without posing a threat of addiction or presenting any of the side effects associated with the stimulant medication. They are also infinitely cheaper to use

Noocube and Mind Lab Pro are more complete solutions while Performance Lab Mind provides a gentler, less powerful approach.

Whichever supplement you choose, make sure to read the label carefully and use it in the recommended way.

Sources of Reference

1. Efficacy of Tablet Huperzine-a on Memory, Cognition, and Behavior in Alzheimer’s Disease: https://pubmed.ncbi.nlm.nih.gov/8701750/
2. Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137276/
3. Alpha-GPC (alfoscerate, L-alpha glycerylphosphorylcholine): https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Alpha-GPC-Cognitive-Vitality-For-Researchers.pdf
4. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235064/
5. Resveratrol and Cognitive Decline: A Clinician Perspective: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657254/
6. Citicoline – A Neuroprotector With Proven Effects on Glaucomatous Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710031/
7. Treatment of ADHD With French Maritime Pine Bark Extract, Pycnogenol: https://pubmed.ncbi.nlm.nih.gov/16699814/
8. Why is vitamin B6 effective in alleviating the symptoms of autism?: https://pubmed.ncbi.nlm.nih.gov/29685187/